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Anti-Matrix Metalloproteinase-25, Propeptide Region antibody produced in rabbit
| 产品编号： | 3375613 |
| 规格： | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Matrix Metalloproteinase-25, Propeptide Region antibody produced in rabbit
Anti-MT6-MMP
Anti-MMP-25
基本信息
| MDL number | MFCD04974754 |
| NACRES | NA.41 |
| General description【一般描述】 | Matrix metalloproteinase-25 (MMP-25) belongs to the membrane-anchored matrix metalloproteinase subfamily. It is produced as a 57-60kDa monomer and is later expressed as a homodimer of 120kDa. This glycophosphatidylinositol (GPI)-anchored metalloproteinase is expressed in the polymorphonuclear neutrophils. MMP-25 possesses an extracellular prodomain along with other functional domains. The gene encoding it is localized on human chromosome 16p13.3. |
| Specificity【特异性】 | By immunoblotting against the reduced protein, the antibody identifies a band at 65 kDa as well as breakdown products. The antibody recognizes the zymogen and not activated forms of the enzyme. |
| Immunogen【免疫原】 | synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-25 (membrane-type matrix metalloproteinase-6). |
| Biochem/physiol Actions【生化/生理作用】 | Matrix metalloproteinase-25 (MMP-25) acts as a marker for chronic respiratory diseases. Studies have indicated that MMP-25 can degrade fibrin, fibronectin, gelatin and type IV collagen. It may have a role in the degradation of the pericellular extracellular matrix. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous glycerol solution |
| species reactivity | human, mouse |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | western blot: 1:1,000 |
| UniProt accession no.【UniProt登记号】 | Q9NPA2 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MMP25(64386) mouse ... Mmp25(240047) |
