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Anti-TRMT12 antibody produced in rabbit
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | TRMT12 (tRNA methyltransferase 12 homolog) gene is localized to human chromosome 8q24, and is a homolog of yeast gene coding for a tRNA methyltransferase. |
| Immunogen【免疫原】 | Antibody was raised against a 19 amino acid peptide near the amino terminus of human TYW2. |
| Biochem/physiol Actions【生化/生理作用】 | TRMT12 (tRNA methyltransferase 12 homolog) gene is amplified and over-expressed in breast cancer. This enzyme is responsible for catalyzing the third step in wybutosine biosynthetic pathway. In cancer, up-regulation of this gene leads to disruption in SMG1 protein function, which is a part of nonsense mediated decay pathway (NMD). Thus, it might contribute to the escape of damaged DNA from checkpoints. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Linkage【联系】 | The action of this antibody can be blocked using blocking peptide SBP3500666. |
| Physical form【外形】 | Supplied at 1 mg/mL in PBS with 0.02% sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| mol wt【分子量】 | 49 kDa |
| species reactivity | mouse, human |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | ELISA: suitable immunocytochemistry: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q53H54 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... TRMT12(55039) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
