PP2C-α, active, GST tagged human

NA.32

Protein phosphatase 2C-α (PP2C-α), also called protein phosphatase, Mg²⁺/Mn²⁺ dependent 1A (PPM1A), is a member of the family of Ser/Thr protein phosphatases and is composed of a catalytic subunit and a constant regulatory subunit. PP2C-α is highly expressed in heart and skeletal muscle. The gene encoding this protein is localized on human chromosome 4q12.

Protein phosphatase 2C-α (PP2C-α) or PPM1A is known to be negative regulators of cell stress response pathways. It has been reported to negatively regulate TGF-β signaling pathway and cell cycle. PP2C-α has been shown to dephosphorylate cyclin-dependent kinases (CDKs) and it may be involved in cell cycle control. It modulates cell migration and invasion. Overexpression of PP2C-α is reported to cause cell-growth arrest or cell death.

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

After opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles.

human

expressed in baculovirus infected Sf9 cells

≥70% (SDS-PAGE)

buffered aqueous glycerol solution

960-1440 nmol/min·mg

~105 kDa

NM_021003

cell analysis

dry ice

−70℃

human ... PPM1A(5494)

10 - Combustible liquids

WGK 1