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Topiroxostat
产品别名
577778-58-6
Topiroxostat
FYX 051
FYX-051
4-[3-(4-Pyridinyl)-1H-1,2,4-triazol-5-yl]-2-pyridinecarbonitrile
5-(2-Cyano-4-pyridyl)-3-(4-pyridyl)-1,2,4-triazole
4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C13H8N6 |
| Molecular weight | 248.24 |
| MDL number | MFCD17167057 |
| Biochem/physiol Actions【生化/生理作用】 | Topiroxostat (FYX-051) is an orally active and potent inhibitor of xanthine oxidoreductase (XOR). It appears that inhibition of XOR by topiroxostat is due to the formation a covalent linkage to molybdenum via oxygen in the hydroxylation reaction intermediate. Also, topiroxostat displayed a potent, non-covalent inhibition of XOR. It is approved for the treatment of gout and hyperuricemia in Japan. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | N#CC1=NC=CC(C2=NNC(C3=CC=NC=C3)=N2)=C1 |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
