2,3-Butanedione 2-Monoxime-CAS 57-71-6-Calbiochem

C₄H₇NO₂

101.10

MFCD00002116

An inhibitor of skeletal and cardiac muscle contraction. A "chemical phosphatase" that dephosphorylates acetylcholinesterase poisoned with organophosphates. Inhibits Ca²⁺ currents in adult rat cervical ganglion in a reversible and dose-dependent manner (IC₅₀ = 18.3 nM). Also shown to induce Ca²⁺ release from canine cardiac sarcoplasmic reticulum (SR).
An inhibitor of skeletal and cardiac muscle contraction. A general reversible inhibitor of myosin ATPase in eukaryotes. A “chemical phosphatase,” which dephosphorylates acetylcholinesterase poisoned with organophosphates. Inhibits Ca²⁺ currents in adult rat cervical ganglion in a reversible and dose-dependent manner (IC₅₀ = 18.3 nM). Also shown to induce Ca²⁺ release from canine cardiac sarcoplasmic reticulum (SR).

Target IC₅₀: 18.3 nM inhibiting Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner
Primary Target
Ca²⁺ currents in adult rat cervical ganglion in a reversible and dose-dependent manner
Product does not compete with ATP.
Cell permeable: no
Reversible: yes

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Phillips, R.M., and Altschuld, R.A. 1996. Biochem. Biophys. Res. Commun.229, 154.
Sellin, L.C., and McArdle, J.J. 1994. Pharmacol. Toxicol.74, 305.
Zhu, Y., and Ikeda, S.R. 1993. Neurosci.Lett. 155, 24.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (GC)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

white to off-white

methanol: 100 mg/mL

ambient

2-8℃

1S/C4H7NO2/c1-3(5-7)4(2)6/h7H,1-2H3/b5-3+

FSEUPUDHEBLWJY-HWKANZROSA-N

500 mg in Plastic ampoule

11 - Combustible Solids

WGK 3