HIF-2α Translation Inhibitor-CAS 882268-69-1-Calbiochem

C₉H₉N₃O₄S₂

287.32

A cell-permeable thienylhydrazone compound that suppresses the translation of cellular HIF-2α message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5′ UTR of the HIF-2α mRNA, exhibiting otherwise no effects toward the transcription of HIF-2α mRNA or the stability of HIF-2α mRNA and protein. Shown to reduce cellular protein levels of HIF-2α and HIF-2α target genes, including Glut-1, IGFBP3, and VEGF, in 786-O cells (5-10 µM final concentration) that express only the 2α isoform of hypoxia-inducible factor.
A cell-permeable thienylhydrazone compound that suppresses the translation of cellular HIF-2α message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5′ UTR of the HIF-2α mRNA, exhibiting otherwise no effects toward the transcription of HIF-2α mRNA or the stability of HIF-2α mRNA and protein. Shown to reduce cellular protein levels of HIF-2α and HIF-2α target genes, including Glut-1, IGFBP3, and VEGF, in 786-O cells (5 to 10 µM final concentration) that express only the 2α isoform of hypoxia-inducible factor.

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Zimmer, M., et al. 2008. Mol. Cell32, 838.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

200

≥95% (sum of two isomers)

solid

Calbiochem^®

OK to freeze
protect from light

amber

DMSO: 5 mg/mL

ambient

2-8℃

10 mg in Glass bottle
Packaged under inert gas

11 - Combustible Solids

WGK 3