Pamidronate, Disodium Salt-CAS 109552-15-0-Calbiochem

C₃H₉NO₇P₂ · 2Na · 5H₂O

369.11

A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget’s disease, hypercalcaemia of malignancy, osteolytic bone metastasis, steroid-induced osteoporosis, and idiopathic osteoporosis. Inhibits breast cancer cell growth by inducing cell death in vitro. Provided in hydrated form, contains five molecules of water.
A calcium metabolism regulator. A potent and specific inhibitor of bone resorption at doses devoid of any significant detrimental effect on bone growth and mineralization. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget′s disease, hypercalcemia of malignancy, osteolytic bone metastasis, and steroid-induced cell death in vitro. Provided in a hydrated form containing five molecules of water.

Primary Target
Inhibitor of bone resorption
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.

Fromigue, O., et al. 2000. J. Bone Miner. Res.15, 2211.
Fitton, A., and McTravish, D. 1991. Drugs41, 289.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

white

water: 10 mg/mL

ambient

−20℃

1S/C3H11NO7P2.2Na.5H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;;;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;5*1H2/q;2*+1;;;;;/p-2

CZYWHNTUXNGDGR-UHFFFAOYSA-L

10 mg in Plastic ampoule

GHS07

Warning

H302 - H319

P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313

Acute Tox. 4 Oral - Eye Irrit. 2

11 - Combustible Solids

WGK 3