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Cdc25 Inhibitor IV, NSC 95397-CAS 93718-83-3-Calbiochem
| 产品编号： | 4155565 |
| 规格： | The Cdc25 Inhibitor IV, NSC 95397, also referenced under CAS 93718-83-3, controls the biological activity of Cdc25. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| CAS NO： | 93718-83-3 |
| 包装规格： | 10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4155565 | 10 MG | 2150 | 2-5天 | 4-6周 |
产品别名
93718-83-3
Cdc25 Inhibitor IV, NSC 95397-CAS 93718-83-3-Calbiochem
(2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H14O4S2 |
| Molecular weight | 310.39 |
| MDL number | MFCD04040032 |
| General description【一般描述】 | A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50 = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Dulyaninova, N.G., et al. 2011. Biochemistry50, 7218. Lazo, J.S., et al. 2002. Mol. Pharmacol.61, 720. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | orange |
| solubility【溶解性】 | DMSO: 100 mg/mL, clear, red |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C1C(SCCO)=C(SCCO)C(C2=CC=CC=C21)=O |
| InChI | 1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2 |
| InChI key | MAASHDQFQDDECQ-UHFFFAOYSA-N |
| packaging【包装】 | 10 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
