DL-threo-PDMP, Hydrochloride-CAS 80938-69-8-Calbiochem

C₂₃H₃₈N₂O₃ · xHCl

390.56 (free base basis)

MFCD00236490

PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme. Blocks the outgrowth of neurites and inhibits glycolipid synthesis in cultured NIH/3T3 cells.
PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and is a potent and competitive inhibitor of this enzyme. Blocks the outgrowth of neurites and inhibits glycolipid synthesis in cultured 3T3 cells.

Primary Target
glycolipid synthesis in cultured NIH/3T3 cells
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Toxicity: Irritant (B)

Rani, C.S., et al. 1995. J. Biol. Chem. 270, 2859.
Rosenwald, A.G. 1992. Biochemistry31, 3581.
Inokuchi, J., and Radin, N.S. 1987. J. Lipid Res.28, 565.
Vunnam, R.R., and Radin, N.S. 1980. Chem. Phys. Lipids26, 265.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (TLC)

solid

Calbiochem^®

OK to freeze

white

DMSO: soluble
ethanol: soluble
methanol: soluble

ambient

−20℃

50 mg in Plastic ampoule

11 - Combustible Solids

WGK 3