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Fmoc-ACA-OH
产品别名
378247-75-7
Fmoc-ACA-OH
7-N-Fmoc-aminocoumarin-4-acetic acid
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H19NO6 |
| Molecular weight | 441.43 |
| General description【一般描述】 | Fmoc-ACA-OH is a useful tool for the SPPS of AMC fluorogenic protease substrates. Fmoc-ACA-OH [1] must be first loaded onto a Wang-type resin. Any unreacted linker hydroxyls must be capped using acetic anhydride. Following Fmoc removal, the first amino acid should be coupled withy HATU/collidine [2]. Insertion of ACA into the middle of a peptide provides fluorogenic substrates for endopeptidases [3]. Treatment of the ACC peptide obtained after TFA cleavage with aqueous base causes facile decarboxylation and formation of the AMC peptide. |
| Analysis Note【分析说明】 | Color (visual): white to slight yellow to light red Appearance of substance (visual): powder Identity (IR): passes test Purity (TLC(CMA1)): ≥ 98 % Assay (HPLC, area%): ≥ 95.0 % (a/a) Solubility (1 mmole in 2 ml DMF): clearly soluble For TLC-Systems see our General Catalog |
| Legal Information【法律信息】 | Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 200 |
| product line【产品线】 | Novabiochem® |
| Assay【测定】 | ≥95.0% (HPLC) ≥98% (TLC) |
| form【形式】 | powder |
| reaction suitability | reaction type: Fmoc solid-phase peptide synthesis |
| manufacturer/tradename | Novabiochem® |
| functional group【官能团】 | Fmoc |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
