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GPR120 Agonist III-Calbiochem
| 产品编号： | 4157245 |
| 规格： | The GPR120 Agonist III controls the biological activity of GPR120. This small molecule/inhibitor is primarily used for Activators/Inducers applications. |
| 包装规格： | 25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
GPR120 Agonist III-Calbiochem
3-(4-((4-Fluoro-4'-methyl-(1,1'-biphenyl)-2-yl)methoxy)-phenyl)propanoic acid
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C23H21FO3 |
| Molecular weight | 364.41 |
| MDL number | MFCD22421654 |
| General description【一般描述】 | A membrane-permeant biphenyl-methoxy-phenylpropanoate compound that acts as an active-site targeting, selective, potent agonist of G-protein coupled receptor 120/GPR120 (EC50 of β-arrestin 2 recruitment = 17 nM and 44 nM for mGPR120 and hGPR120, respectively; EC50 of Ca++ mobilization = 96 nM for hGPR120). Exhibits much reduced potency toward free fatty acid receptor 1/FFA1/GPR40 (EC50 of β-arrestin 2 recruitment = 64.6 µM) and no activity toward short chain FFA receptors FFA2/GPR43 and FFA3/GPR41. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target G-protein coupled receptor 120 Reversible: yes |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Shimpukade, B., et al. 2012. J. Med. Chem.55, 4511. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 100 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(O)CCC1=CC=C(OCC2=CC(F)=CC=C2C3=CC=C(C)C=C3)C=C1 |
| packaging【包装】 | 25 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
