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InSolution Cyclopamine-KAAD-Calbiochem
| 产品编号： | 4157511 |
| 规格： | A cell-permeable potent analog of Cyclopamine that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity. |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
InSolution Cyclopamine-KAAD-Calbiochem
3- Keto-N-( aminoethyl- aminocaproyl- dihydrocinnamoyl)cyclopamine
3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥70% (sum of two isomers, HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| packaging【包装】 | 50 μg in Glass bottle Packaged under inert gas |
基本信息
| General description【一般描述】 | A cell-permeable potent analog of Cyclopamine (>Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both ShhNp-induced pathway activity and SmoA1-induced reporter activity. Reported to cause regression of murine tumor allografts in vivo and induce rapid cell death in human medulloblastoma. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. The solid form of this compound (Cat. No. 239804) is also available. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target SmoA1 |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 1 mM (50 µg/72 µL) solution of Cyclopamine-KAAD (Cat. No. 239804) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. |
| Other Notes【其他说明】 | Siegelin, M.D. et al. 2009. Neurobiol. Dis.34, 259. Watkins, D.N., et al. 2003. Nature422, 313. Berman, D.M., et al. 2002. Science297, 1559. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071. Chen, J.K., et al. 2002. Genes Dev.16, 2743. Frank-Kamenetsky, M., et al. 2002. J. Biol.1, 10. Taipale, J., et al. 2000. Nature406, 1005. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (refers to pure substance) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (refers to pure substance) |
