KLF5 Inhibitor, CID 5951923-CAS 749872-43-3-Calbiochem

C₁₆H₁₈N₂O₇S

382.39

MFCD04796932

A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC₅₀ = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr¹⁰⁶⁸ and ERK1/2-Thr²⁰²/Tyr²⁰⁴. Also, up-regulates the phosphorylation of p38 MAPK-Thr¹⁸⁰/Tyr¹⁸².
A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC₅₀ = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr¹⁰⁶⁸ and ERK1/2-Thr²⁰²/Tyr²⁰⁴. Also, up-regulates the phosphorylation of p38 MAPK-Thr¹⁸⁰/Tyr^182.

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock Solutions are stable for up to 3 months at -20°C.

Bialkowska, A., et al. 2011. Mol. Cancer Ther.10, 2043.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥99% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

off-white

DMSO: 50 mg/mL

ambient

2-8℃

10 mg in Glass bottle
Packaged under inert gas

11 - Combustible Solids

WGK 3