Mitochondrial Division Inhibitor, mdivi-1-CAS 338967-87-6-Calbiochem

C₁₅H₁₀Cl₂N₂O₂S

353.22

MFCD00974506

NA.77

A cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC₅₀ = 10 and 50 M in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC₅₀<10 M) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release.

Toxicity: Standard Handling (A)

Cassidy-Stone A., et al. 2008. Dev. Cell14, 193.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

white

DMSO: 10 mg/mL

wet ice

−20℃

10 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3