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RAGE Antagonist Peptide, RAP-Calbiochem
| 产品编号： | 4168747 |
| 规格： | The RAGE Antagonist Peptide, RAP controls the biological activity of RAGE. |
| 包装规格： | 10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
RAGE Antagonist Peptide, RAP-Calbiochem
ELKVLMEKEL
基本信息
| Empirical Formula【经验(实验)分子式】 | C57H101N13O17S |
| Molecular weight | 1272.55 |
| General description【一般描述】 | An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models. |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target RAGE Reversible: yes |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | Ac-ELKVLMEKEL-NH2 |
| Physical form【外形】 | Supplied as a trifluoroacetate salt. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Arumugam, T., et al. 2012. Clin Cancer Res.18, 4356. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | powder |
| potency【效能】 | 2 μM IC50 |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | water: 5 mg/mL |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 10 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
