STAT3 抑制剂 V，Stattic-CAS 19983-44-9-Calbiochem

C₈H₅NO₄S

211.19

MFCD00173799

A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr⁷⁰⁵ with little effect towards STAT1 phosphorylation at Tyr⁷⁰¹ (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
STAT3

Toxicity: Irritant (B)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.

Schust, J., et al. 2006. Chem. Biol.13, 1235.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

pale yellow

DMSO: 10 mg/mL
ethanol: 5 mg/mL

ambient

2-8℃

25 mg in Plastic Bag(s)
Packaged under inert gas

11 - Combustible Solids

WGK 3