VEGF Inducer, GS4012-CAS 328073-92-3-Calbiochem

C₁₄H₁₅NOS · xHCl

245.34 (free base basis)

A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation. GS4012-induced upregulation of VEGF correlates well with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs.
A cell-permeable and potent inducer of VEGF and VEGF-mediated blood vessel formation. GS4012-induced upregulation of VEGF correlates with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs. An essential molecule required during angioblasts cell fate determination.

Cell permeable: yes
Primary Target
Potent inducer of VEGF and VEGF-mediated vessel formation
Product does not compete with ATP.
Reversible: no

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Peterson, R.T., et al. 2004. Nat. Biotechnol.22, 595.
Depre, C., et al. 2003. Circulation108, 2723.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (HPLC)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)
protect from light

white

DMSO: 200 mg/mL
methanol: 50 mg/mL
water: soluble

ambient

2-8℃

10 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1